The development of tolerance to the anticonvulsant effects of clonazepam, but not sodium valproate, in the amygdaloid kindled rat

Neuropharmacology. 1987 Nov;26(11):1611-4. doi: 10.1016/0028-3908(87)90010-4.


The effects of chronic treatment with clonazepam and sodium valproate were studied on kindled amygdaloid seizures in rats. Fully kindled rats were given an intraperitoneal (i.p.) injection of either vehicle (1.0 ml/kg), clonazepam (0.3 mg/kg) or sodium valproate (200 mg/kg) twice daily for 12 days. Each rat was stimulated through an amygdaloid electrode 30 min after the morning dose. While both drugs initially blocked and kindled seizure (P less than 0.01), the results showed a significant trend (P less than 0.02) in the development of tolerance to the anticonvulsant action of clonazepam but no significant tolerance to the action of valproate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amygdala / drug effects*
  • Animals
  • Anticonvulsants*
  • Clonazepam / pharmacology*
  • Drug Tolerance
  • Kindling, Neurologic / drug effects*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Seizures / physiopathology
  • Valproic Acid / pharmacology*


  • Anticonvulsants
  • Clonazepam
  • Valproic Acid