Second primary tumors in patients with a head and neck paraganglioma

Head Neck. 2019 Sep;41(9):3356-3361. doi: 10.1002/hed.25849. Epub 2019 Jun 25.

Abstract

Background: There are conflicting recommendations and possibly overuse of imaging for surveillance of second primary tumors for patients with a history of head and neck paraganglioma.

Methods: Retrospective cohort study of 234 adults with head and neck paragangliomas (1990-2010) followed for a mean of 7.5 ± 8.4 years.

Results: The rate of second paraganglioma was 1.7% after 5 years and 5.1% after 10 years, yielding an incidence of 6.65 per 1000 person-years. Only 1.3% of patients (2.59 per 1000 person-years) ever had a second paraganglioma in the chest, abdomen, or pelvis. Patients with a hereditary paraganglioma (hazard ratio [HR] = 4.84, 95% confidence interval [CI]: 1.52-15.43) or carotid body tumor (HR = 3.55, 95% CI: 1.15-10.99) were at greater risk.

Conclusions: The incidence rate of a second primary paragangliomas is low but increases with hereditary disease. These results question the utility of repeated imaging outside of the neck to screen for second paragangliomas.

Keywords: glomus tumor; imaging; paraganglioma; second primary tumor; surveillance.

MeSH terms

  • Adult
  • Aged
  • Female
  • Head and Neck Neoplasms / diagnosis*
  • Head and Neck Neoplasms / epidemiology*
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / diagnosis*
  • Neoplasms, Second Primary / epidemiology*
  • Paraganglioma / diagnosis*
  • Paraganglioma / epidemiology*
  • Retrospective Studies
  • Risk Factors
  • Time Factors