Central compartment involvement in aspirin-exacerbated respiratory disease: the role of allergy and previous sinus surgery

Int Forum Allergy Rhinol. 2019 Sep;9(9):1017-1022. doi: 10.1002/alr.22367. Epub 2019 Jun 27.


Background: Evidence for a relationship between allergy and chronic rhinosinusitus with nasal polyps (CRSwNP) is equivocal. Central compartment (CC) atopic disease is a nasal inflammatory condition related to inhalant allergy. CC involvement is common in aspirin-exacerbated respiratory disease (AERD), a subset of CRSwNP, and we hypothesize it is related to allergic status.

Methods: This study was a retrospective analysis of a single-institution database for the January 2016 to February 2019 time period. Data regarding endoscopic CC findings, clinical allergy history, and results of allergy testing were collected. Statistical analysis was performed, with significance set at p < 0.05.

Results: Seventy-two AERD patients met the inclusion criteria. Fifty-nine patients had CC involvement (53 bilateral, 6 unilateral). For patients with documented allergy status, 100% of patients with endoscopic CC disease had clinical allergic rhinitis (AR), and 45 of 48 (93.8%) had positive allergy testing. Thirteen patients had no CC involvement (4 with clinical AR; 3 of 7 with positive allergy testing). CC endoscopic findings in AERD were significantly associated with clinical allergy (p < 0.0001, phi = 0.771). Overall, patients with CC involvement averaged 3.8 surgeries vs 3.2 for those without CC involvement (p = not statistically significant). However, patients with septal involvement averaged 4.2 surgeries vs 2.0 for those without septal involvement (p = 0.004). As the number of sinus surgeries increases, middle turbinate (MT) resection (r = 0.300, p = 0.022) and septal involvement (r = 0.372, p = 0.004) significantly increase. All patients with MT resection had septal disease, whereas none without CC disease had MT resection.

Conclusion: Most AERD patients exhibit AR, and this correlates with CC disease. As the number of surgeries increases, MT resection may predispose to polyposis of the septum.

Keywords: allergic rhinitis; allergy; aspirin-exacerbated respiratory disease; chronic rhinosinusitis; chronic sinusitis; endoscopic sinus surgery; nasal polyp.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Allergens / immunology
  • Asthma, Aspirin-Induced / epidemiology*
  • Asthma, Aspirin-Induced / surgery
  • Chronic Disease
  • Endoscopy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nasal Polyps / epidemiology*
  • Nasal Polyps / surgery
  • Paranasal Sinuses / surgery*
  • Retrospective Studies
  • Rhinitis, Allergic / epidemiology*
  • Rhinitis, Allergic / surgery
  • Rhinoplasty*
  • Sinusitis / epidemiology*
  • Sinusitis / surgery
  • Young Adult


  • Allergens