Persistence of the immune response after 4CMenB vaccination, and the response to an additional booster dose in infants, children, adolescents, and young adults

Hum Vaccin Immunother. 2019;15(12):2940-2951. doi: 10.1080/21645515.2019.1627159. Epub 2019 Jul 9.


The multicomponent meningococcal serogroup B vaccine, 4CMenB, has demonstrated effectiveness in preventing invasive MenB disease in infants and in controlling MenB outbreaks. The need for/timing of additional booster doses is not yet established. We reviewed eight studies that evaluated antibody persistence and booster following primary 4CMenB vaccination of infants, children, adolescents, and young adults. Putative seroprotective hSBA titers for ≥1 vaccine antigen were maintained by 76-100% of children 24-36 months after priming during infancy and in 84-100% after priming in the second year of life. hSBA levels were higher in vaccinees at 4 and 7.5 years following priming during adolescence than in vaccine-naïve individuals of a similar age. Antibodies persisted at higher levels to NHBA and NadA than to PorA or fHbp. Booster vaccination induced robust anamnestic responses, demonstrating effective priming by 4CMenB across age-groups. These data can inform decision-making to optimize vaccination strategies.

Keywords: 4CMenB; Neisseria meningitidis; antibody persistence; immunogenicity; meningococcal serogroup B.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / blood*
  • Clinical Studies as Topic
  • Female
  • Humans
  • Immunization Schedule*
  • Immunization, Secondary*
  • Immunogenicity, Vaccine
  • Infant
  • Male
  • Meningococcal Infections / prevention & control*
  • Meningococcal Vaccines / administration & dosage*
  • Serogroup
  • Young Adult


  • 4CMenB vaccine
  • Antibodies, Bacterial
  • Meningococcal Vaccines

Grant support

GlaxoSmithKline Biologicals SA funded all costs associated with the development and the publishing of the present manuscript.