Research progress in the relationship between type 2 diabetes mellitus and intestinal flora

Biomed Pharmacother. 2019 Sep;117:109138. doi: 10.1016/j.biopha.2019.109138. Epub 2019 Jun 24.


Type 2 diabetes mellitus (T2DM) is a common clinical chronic disease, while its pathogenesis is still inconclusive. Intestinal flora, the largest micro-ecological system in the human body, is involved in, meanwhile has a major impact on the body's material and energy metabolism. Recent studies have shown that in addition to obesity, genetics, and islet dysfunction, the disturbance of intestinal flora may partly give rise to diabetes. In this paper, we summarized the current research on the correlation between T2DM and intestinal flora, and concluded the pathological mechanisms of intestinal flora involved in T2DM. Moreover, the ideas and methods of prevention and treatment of T2DM based on intestinal flora were proposed, providing theoretical basis and literature reference for the treatment of T2DM and its complications based on the regulation of intestinal flora.

Keywords: Intestinal flora; Research progress; Type 2 diabetes mellitus.

Publication types

  • Review

MeSH terms

  • Biomedical Research*
  • Diabetes Mellitus, Type 2 / microbiology*
  • Diabetes Mellitus, Type 2 / prevention & control
  • Diabetes Mellitus, Type 2 / therapy
  • Fatty Acids / metabolism
  • Fecal Microbiota Transplantation
  • Gastrointestinal Microbiome*
  • Humans
  • Models, Biological


  • Fatty Acids