A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

J Exp Med. 2019 Sep 2;216(9):1999-2009. doi: 10.1084/jem.20190689. Epub 2019 Jun 27.


Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, White / cytology*
  • Animals
  • Cell Proliferation
  • Eosinophils / metabolism
  • Immunity, Innate*
  • Interleukin-33
  • Interleukin-5 / biosynthesis
  • Lymphocytes / cytology*
  • Lymphocytes / immunology*
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Stromal Cells / cytology


  • Interleukin-33
  • Interleukin-5