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Recent Advances in Personalizing Cardiac Arrest Resuscitation


Recent Advances in Personalizing Cardiac Arrest Resuscitation

Cyrus E Kuschner et al. F1000Res.


Cardiac arrest remains a significant cause of death and disability throughout the world. However, as our understanding of cardiac arrest and resuscitation physiology has developed, new technologies are fundamentally altering our potential to improve survival and neurologic sequela. Some advances are relatively simple, requiring only alterations in current basic life support measures or integration with pre-hospital organization, whereas others, such as extra-corporeal membrane oxygenation, require significant time and resource investments. When combined with consistent rescuer and patient-physiologic monitoring, these innovations allow an unprecedented capacity to personalize cardiac arrest resuscitation to patient-specific pathophysiology. However, as more extensive options are established, it can be difficult for providers to incorporate novel resuscitation techniques into a cardiac arrest protocol which can fit a wide variety of cases with varying complexity. This article will explore recent advances in our understanding of cardiac arrest physiology and resuscitation sciences, with particular focus on the metabolic phase after significant ischemia has been induced. To this end, we establish a practical consideration for providers seeking to integrate novel advances in cardiac arrest resuscitation into daily practice.

Keywords: CPR; Cardiac Arrest; Cardiopulmonary Resuscitation; Metabolic Phase; Resuscitation.

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.


Figure 1.
Figure 1.. Hierarchical model of modern resuscitation.
ACLS, advanced cardiac life support; CA, cardiac arrest; CPR, cardiopulmonary resuscitation; RQ, respiratory quotient; VCO 2, ventilatory carbon dioxide; VO 2, ventilatory oxygen.
Figure 2.
Figure 2.. Contextualizing novel cardiac arrest interventions on the basis of phase of cardiac arrest.
AED, automated external defibrillation; CA, cardiac arrest; CPR, cardiopulmonary resuscitation; ECMO, extra-corporeal mechanical oxygenation; TCO 2/CO, total carbon dioxide/cardiac output.

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Grant support

The author(s) declared that no grants were involved in supporting this work.

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