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Case Reports
, 11 (4), e4480

Dedifferentiated Liposarcoma in a Giant Esophageal Polyp: A Case Report and Review of the Literature

Case Reports

Dedifferentiated Liposarcoma in a Giant Esophageal Polyp: A Case Report and Review of the Literature

Malav P Parikh et al. Cureus.


Soft tissue sarcomas represent an extremely rare cause of esophageal masses, and undifferentiated sarcomas are rarer. The proportion of dedifferentiated liposarcomas (DDL) is even lower. The case of a 58-year-old male who complained of dysphagia and was found to have an 18-centimeter long esophageal mass/polyp on esophagogastroduodenoscopy is presented. The lesion was resected endoscopically and a diagnosis of DDL was confirmed by fluorescence in situ hybridization. Due to its rarity, the treatment experience with esophageal DDLs is limited. However, based on our experience, endoscopic resection of the lesion can be considered as the treatment of choice when feasible. We performed a review of the literature to identify and analyze similar reported cases.

Keywords: endoscopic release; esophageal cancer; fluorescence in situ hybridization; liposarcoma; neoplasia.

Conflict of interest statement

The authors have declared that no competing interests exist.


Figure 1
Figure 1. Giant esophageal polyp originating near the cricopharyngeus
Figure 2
Figure 2. Mid portion of the lesion with a large multi-lobulated mass
Figure 3
Figure 3. Endoscopic resection of the lesion at the tumor base
Figure 4
Figure 4. Resected esophageal mass in the stomach
Figure 5
Figure 5. Well-differentiated liposarcoma component characterized by adipocytes, myxoid change, and scattered atypical cells
Figure 6
Figure 6. Dedifferentiated component with fascicles of hyper-cellular spindle cells without lipogenic differentiation

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