The PSIPRED Protein Analysis Workbench: 20 Years On

Nucleic Acids Res. 2019 Jul 2;47(W1):W402-W407. doi: 10.1093/nar/gkz297.


The PSIPRED Workbench is a web server offering a range of predictive methods to the bioscience community for 20 years. Here, we present the work we have completed to update the PSIPRED Protein Analysis Workbench and make it ready for the next 20 years. The main focus of our recent website upgrade work has been the acceleration of analyses in the face of increasing protein sequence database size. We additionally discuss any new software, the new hardware infrastructure, our webservices and web site. Lastly we survey updates to some of the key predictive algorithms available through our website.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Gene Ontology / history
  • Gene Ontology / trends*
  • History, 21st Century
  • Internet
  • Models, Molecular
  • Molecular Sequence Annotation / history
  • Molecular Sequence Annotation / methods*
  • Protein Binding
  • Protein Conformation, alpha-Helical
  • Protein Conformation, beta-Strand
  • Protein Interaction Domains and Motifs
  • Proteins / chemistry*
  • Proteins / history
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Software / history*


  • Proteins