Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes

J Diabetes Complications. 2019 Sep;33(9):648-650. doi: 10.1016/j.jdiacomp.2019.05.023. Epub 2019 Jun 3.

Abstract

Early diabetic kidney disease (DKD) occurs in adolescents with type 1 diabetes (T1D). Lower serum uromodulin (SUMOD) predicts DKD progression in adults with T1D. In this study, we demonstrate that lower SUMOD is associated with urinary albumin excretion in adolescents with T1D, suggesting a potential relationship between SUMOD and early kidney dysfunction in T1D youth.

Keywords: Adolescents; Arterial stiffness; Glomerular filtration rate; Serum uromodulin; Type 1 diabetes; Urinary albumin excretion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Albuminuria / blood*
  • Biomarkers / blood
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / urine
  • Diabetic Nephropathies / blood
  • Diabetic Nephropathies / physiopathology
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney / physiopathology
  • Male
  • Uromodulin / blood*
  • Young Adult

Substances

  • Biomarkers
  • Uromodulin