Total Parental Nutrition Using Conventional and Medium Chain Triglycerides: Effect on Liver Function Tests, Complement, and Nitrogen Balance

JPEN J Parenter Enteral Nutr. Jan-Feb 1988;12(1):15-9. doi: 10.1177/014860718801200115.

Abstract

Conventional long chain triglyceride (LCT) was compared with a new emulsion containing 50% medium chain triglyceride (5% MCT/5% LCT) in a randomized cross-over trial of 10 days duration. Plasma concentrations of albumin, prealbumin, the complement components C3 and C4, and prothrombin times measured daily at 8 am, before lipid infusion, showed no progressive change during the 10 days of the trial, nor in each separate 5-day period when LCT or MCT/LCT was infused. Aspartate transaminase and alkaline phosphatase activities were similar over the two periods. There was a significant increase (compared with preinfusion levels) in C3 and C4 levels after 5 hr of either lipid infusion. Nitrogen balance was improved, and plasma bilirubin levels were lower on the regimen containing MCT/LCT.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Bilirubin / blood
  • Complement C3 / analysis*
  • Complement C4 / analysis*
  • Drug Combinations / pharmacology
  • Fat Emulsions, Intravenous / administration & dosage
  • Fat Emulsions, Intravenous / pharmacology*
  • Female
  • Glycerol / pharmacology
  • Humans
  • Liver / drug effects
  • Liver / physiopathology*
  • Liver Function Tests
  • Male
  • Middle Aged
  • Molecular Weight
  • Nitrogen / metabolism*
  • Parenteral Nutrition, Total / methods*
  • Phospholipids / pharmacology
  • Prospective Studies
  • Soybean Oil / pharmacology
  • Triglycerides / administration & dosage
  • Triglycerides / metabolism
  • Triglycerides / pharmacology*

Substances

  • Complement C3
  • Complement C4
  • Drug Combinations
  • Fat Emulsions, Intravenous
  • Phospholipids
  • Triglycerides
  • Lipofundin S
  • Soybean Oil
  • Nitrogen
  • Glycerol
  • Bilirubin