Beta-Lactam and Sulfonamide Allergy Testing Should Be a Standard of Care in Immunocompromised Hosts

Jason A Trubiano; Monica A Slavin; Karin A Thursky; M Lindsay Grayson; Elizabeth J Phillips

doi:10.1016/j.jaip.2019.05.051

Beta-Lactam and Sulfonamide Allergy Testing Should Be a Standard of Care in Immunocompromised Hosts

J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2151-2153. doi: 10.1016/j.jaip.2019.05.051. Epub 2019 Jun 13.

Authors

Jason A Trubiano¹, Monica A Slavin², Karin A Thursky³, M Lindsay Grayson⁴, Elizabeth J Phillips⁵

Affiliations

¹ Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Parkville, VIC, Australia; The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, VIC, Australia. Electronic address: jason.trubiano@austin.org.au.
² Department of Infectious Diseases, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, VIC, Australia.
³ Department of Infectious Diseases, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, VIC, Australia; National Centre for Antimicrobial Stewardship, Royal Melbourne Hospital, Parkville, VIC, Australia.
⁴ Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Parkville, VIC, Australia.
⁵ Department of Infectious Diseases, Vanderbilt University Medical Centre, Nashville, Tenn; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia.

Abstract

Antibiotic allergies are reported in up to 1 in 4 immunocompromised hosts with significant impacts on antibiotic utilization and patient outcomes. Health services programs focused on de-labeling beta-lactam and sulfonamide allergy labels should be a standard of care in immunocompromised hosts.

Keywords: Antibiotic allergy; Antibiotic allergy testing; Penicillin allergy; Penicillin allergy testing.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents / adverse effects*
Chemoprevention / methods
Drug Hypersensitivity / diagnosis*
Drug Hypersensitivity / etiology
Humans
Immunocompromised Host*
Penicillins / adverse effects
Self Report
Skin Tests
Sulfonamides / adverse effects*
Trimethoprim, Sulfamethoxazole Drug Combination / adverse effects
beta-Lactams / adverse effects*

Substances

Anti-Bacterial Agents
Penicillins
Sulfonamides
beta-Lactams
Trimethoprim, Sulfamethoxazole Drug Combination

Grants and funding

P50 GM115305/GM/NIGMS NIH HHS/United States