Assessing the Effect of Vitamin D Replacement on Basal Cell Carcinoma Occurrence and Recurrence Rates in Patients with Vitamin D Deficiency

Horm Cancer. 2019 Dec;10(4-6):145-149. doi: 10.1007/s12672-019-00365-2. Epub 2019 Jun 28.


The study aimed to determine whether 25-OH vitamin D3 deficiency is present in patients with diagnosed BCC, and the effect of vitamin D replacement on the rates of BCC recurrence in patients with 25-OH vitamin D3 deficiency. In this prospective study, between 2012 and 2017, in the first stage, 25-OH vitamin D3 levels of all patients diagnosed with BCC between 2012 and 2013 were evaluated. In the second stage between 2014 and 2015, we evaluated the 25-OH vitamin D3 level of patients who had 25-OH vitamin D3 level < 25 ng/mL. All the patients included in the second stage had BCC recurrence. In the third stage, the patients who were diagnosed 25-OH vitamin D3 deficiency with BCC, between 2015 and 2017, were studied. The mean 25-OH vitamin D3 level of the patients in the second stage was 10.12 ng/mL. Recurrence was observed in 9.64% of the patients in the second stage. The mean level of serum 25-OH vitamin D3 in the third stage was 40.1 ng/mL, and 3.49% of these patients presented with recurrence. In all the patients as the initial diagnosis and following the 25-OH vitamin D3 level in all the patients with BCC recurrence, maintaining 25-OH vitamin D3 levels above 25 ng/mL can significantly reduce the recurrence rate.

Keywords: Basal cell carcinoma; Skin cancers; Vitamin D; Vitamin D deficiency.

MeSH terms

  • Aged
  • Carcinoma, Basal Cell / epidemiology*
  • Carcinoma, Basal Cell / prevention & control
  • Female
  • Humans
  • Male
  • Neoplasm Recurrence, Local / epidemiology*
  • Neoplasm Recurrence, Local / prevention & control
  • Prospective Studies
  • Skin Neoplasms / epidemiology*
  • Skin Neoplasms / prevention & control
  • Treatment Outcome
  • Vitamin D / administration & dosage*
  • Vitamin D / blood
  • Vitamin D Deficiency / diagnosis
  • Vitamin D Deficiency / drug therapy*


  • Vitamin D