Relationships between drinking quantity and frequency and behavioral and hippocampal BOLD responses during working memory performance involving allocentric spatial navigation in college students

doi:10.1016/j.drugalcdep.2019.03.030

. 2019 Aug 1:201:236-243.

doi: 10.1016/j.drugalcdep.2019.03.030. Epub 2019 Jun 19.

Relationships between drinking quantity and frequency and behavioral and hippocampal BOLD responses during working memory performance involving allocentric spatial navigation in college students

Affiliations

¹ Developmental Neurocognitive Driving Simulation Research Center (DrivSim Lab), Department of Emergency Medicine, Yale University School of Medicine, 464 Congress Avenue, Suite 272, New Haven, CT, 06519, USA; Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA. Electronic address: barbara.banz@yale.edu.
² Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA. Electronic address: patrick.worhunsky@yale.edu.
³ Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA. Electronic address: brian.pittman@yale.edu.
⁴ Department of Psychological Sciences, University of Connecticut, Bousfield Psychology Building, 406 Babbidge Road, Unit 1020, Storrs, CT, 06269, USA. Electronic address: robert.astur@uconn.edu.
⁵ Department of Community Medicine and Healthcare, University of Connecticut School of Medicine, 195 Farmington Avenue, Suite 210, Farmington, CT, 06032, USA. Electronic address: tennen@uchc.edu.
⁶ Department of Psychology, Trinity College, Life Sciences Center, Hartford, CT, 06106, USA. Electronic address: sarah.raskin@trincoll.edu.
⁷ Department of Psychological Science, Central Connecticut State University, Marcus White 228, 1615 Stanley Street, New Britain, CT, 06050, USA. Electronic address: austad@ccsu.edu.
⁸ Department of Psychological Science, Central Connecticut State University, Marcus White 228, 1615 Stanley Street, New Britain, CT, 06050, USA. Electronic address: woodre@ccsu.edu.
⁹ Department of Psychological Science, Central Connecticut State University, Marcus White 228, 1615 Stanley Street, New Britain, CT, 06050, USA. Electronic address: fallahic@ccsu.edu.
¹⁰ Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA; Department of Neuroscience, Yale University School of Medicine, 200 South Frontage Road, New Haven, CT, 06519, USA; Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT, 06519, USA; The National Center on Addiction and Substance Abuse, Yale University School of Medicine, New Haven, CT, 06519, USA; The Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA. Electronic address: marc.potenza@yale.edu.
¹¹ Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA; Department of Neuroscience, Yale University School of Medicine, 200 South Frontage Road, New Haven, CT, 06519, USA; Olin Neuropsychiatry Research Center, Hartford Hospital/Institute of Living, 200 Retreat Avenue, Hartford, CT, 06114, USA. Electronic address: godfrey.pearlson@yale.edu.

PMID: 31254750
PMCID: PMC7370814
DOI: 10.1016/j.drugalcdep.2019.03.030

Relationships between drinking quantity and frequency and behavioral and hippocampal BOLD responses during working memory performance involving allocentric spatial navigation in college students

Barbara C Banz et al. Drug Alcohol Depend. 2019.

. 2019 Aug 1:201:236-243.

doi: 10.1016/j.drugalcdep.2019.03.030. Epub 2019 Jun 19.

Authors

Affiliations

¹ Developmental Neurocognitive Driving Simulation Research Center (DrivSim Lab), Department of Emergency Medicine, Yale University School of Medicine, 464 Congress Avenue, Suite 272, New Haven, CT, 06519, USA; Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA. Electronic address: barbara.banz@yale.edu.
² Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA. Electronic address: patrick.worhunsky@yale.edu.
³ Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA. Electronic address: brian.pittman@yale.edu.
⁴ Department of Psychological Sciences, University of Connecticut, Bousfield Psychology Building, 406 Babbidge Road, Unit 1020, Storrs, CT, 06269, USA. Electronic address: robert.astur@uconn.edu.
⁵ Department of Community Medicine and Healthcare, University of Connecticut School of Medicine, 195 Farmington Avenue, Suite 210, Farmington, CT, 06032, USA. Electronic address: tennen@uchc.edu.
⁶ Department of Psychology, Trinity College, Life Sciences Center, Hartford, CT, 06106, USA. Electronic address: sarah.raskin@trincoll.edu.
⁷ Department of Psychological Science, Central Connecticut State University, Marcus White 228, 1615 Stanley Street, New Britain, CT, 06050, USA. Electronic address: austad@ccsu.edu.
⁸ Department of Psychological Science, Central Connecticut State University, Marcus White 228, 1615 Stanley Street, New Britain, CT, 06050, USA. Electronic address: woodre@ccsu.edu.
⁹ Department of Psychological Science, Central Connecticut State University, Marcus White 228, 1615 Stanley Street, New Britain, CT, 06050, USA. Electronic address: fallahic@ccsu.edu.
¹⁰ Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA; Department of Neuroscience, Yale University School of Medicine, 200 South Frontage Road, New Haven, CT, 06519, USA; Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT, 06519, USA; The National Center on Addiction and Substance Abuse, Yale University School of Medicine, New Haven, CT, 06519, USA; The Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA. Electronic address: marc.potenza@yale.edu.
¹¹ Department of Psychiatry, Yale University School of Medicine, 1 Church Street, 7thFloor, New Haven, CT, 06511, USA; Department of Neuroscience, Yale University School of Medicine, 200 South Frontage Road, New Haven, CT, 06519, USA; Olin Neuropsychiatry Research Center, Hartford Hospital/Institute of Living, 200 Retreat Avenue, Hartford, CT, 06114, USA. Electronic address: godfrey.pearlson@yale.edu.

PMID: 31254750
PMCID: PMC7370814
DOI: 10.1016/j.drugalcdep.2019.03.030

Abstract

Background: Quantity and frequency of drinking may be used to effectively quantify the severity of alcohol-use. Drinking-severity has been related to neurocognitive impairments in such domains as spatial working memory (SWM). Youth drinking has been associated with altered neurofunctional underpinnings of SWM. The current study examined the relationship between drinking-severity and SWM processing.

Methods: One-hundred-and-seventy college drinkers reported the maximum number of drinks in a 24 -h period in the last six-months (quantity) and average number of drinking weeks in the last six-months (frequency). All participants performed a virtual Morris Water Task during fMRI which included trials where the target platform was visible or hidden.

Results: Greater quantity was associated with reduced SWM-related activity in the dorsolateral prefrontal cortex (F(1, 167) = 4.15, p = .04). Greater frequency was associated with reduced SWM-related activity in the hippocampus (F(1, 167) = 4.34, p = 0.039). Greater quantity was associated with longer search times (r = 0.21, p = .005) and greater platforms found (r = 0.19, p = .01) in VISIBLE trials. We did not find a relationship between drinking quantity or frequency and gender on SWM-related activity, although men found more platforms in both HIDDEN (F(1, 168) = 11.7, p = 0.0008) and VISIBLE (F(1, 168) = 23.0, p < .0001) trials compared to women.

Conclusions: Altered SWM-related hippocampal function relating to alcohol use in young adults raises questions regarding the impact on young adult health and the nature of the findings. Future studies should examine whether these differences may lead to cognitive deficits later in life.

Keywords: Alcohol; College; DLPFC; Hippocampus; Virtual Morris Water Task; fMRI.

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Figures

**Figure 1.**
The Virtual Water Maze Task. Grayscale examples of a VISIBLE trial search with platform and masked walls (A) and a HIDDEN trial with no platforms and unmasked walls (B). Diagram C depicts the presentation timeline of one run. (Folley et al., 2010). Figure S1 is the color version of the task.

**Figure 2.**
Regions of interest for spatial working memory processing during vMWT task focusing on HIDDEN-VISIBLE condition contrasts. The circles represent the regions of interest. Positive activation (yellow-red) represents regions having greater activation during HIDDEN trials, negative activation (blue coloring) represents regions having greater activation during VISIBLE trials. Frontal pole to parieto-occipital fissure scanning cutoffs are represented by dotted lines.

**Figure 3.**
Comparing activation during HIDDEN and VISIBLE search conditions by drinking-severity measure. A. The relationship between DLPFC activation and drinking; B. the relationship between hippocampus activation and drinking frequency.

See this image and copyright information in PMC

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References

1. Ames SL, Wong SW, Bechara A, Cappelli C, Dust M, Grenard JL, Stacy AW, 2014. Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers. Behav. Brain Res 274, 382–389. - PMC - PubMed
1. Antonova E, Parslow D, Brammer M, Dawson GR, Jackson SH, Morris RG, 2009. Age-related neural activity during allocentric spatial memory. Memory 17, 125–143. - PubMed
1. Astur RS, Ortiz ML, Sutherland RJ, 1998. A characterization of performance by men and women in a virtual Morris water task: A large and reliable sex difference. Behav. Brain Res 93, 185–190. - PubMed
1. Astur RS, Taylor LB, Mamelak AN, Philpott L, Sutherland RJ, 2002. Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task. Behav. Brain Res 132, 77–84. - PubMed
1. Astur RS, Tropp J, Sava S, Constable RT, Markus EJ, 2004. Sex differences and correlations in a virtual Morris water task, a virtual radial arm maze, and mental rotation. Behav. Brain Res 151, 103–115. - PubMed

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[1] Ames SL, Wong SW, Bechara A, Cappelli C, Dust M, Grenard JL, Stacy AW, 2014. Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers. Behav. Brain Res 274, 382–389. - PMC - PubMed

[2] Ames SL, Wong SW, Bechara A, Cappelli C, Dust M, Grenard JL, Stacy AW, 2014. Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers. Behav. Brain Res 274, 382–389. - PMC - PubMed

[3] Antonova E, Parslow D, Brammer M, Dawson GR, Jackson SH, Morris RG, 2009. Age-related neural activity during allocentric spatial memory. Memory 17, 125–143. - PubMed

[4] Antonova E, Parslow D, Brammer M, Dawson GR, Jackson SH, Morris RG, 2009. Age-related neural activity during allocentric spatial memory. Memory 17, 125–143. - PubMed

[5] Astur RS, Ortiz ML, Sutherland RJ, 1998. A characterization of performance by men and women in a virtual Morris water task: A large and reliable sex difference. Behav. Brain Res 93, 185–190. - PubMed

[6] Astur RS, Ortiz ML, Sutherland RJ, 1998. A characterization of performance by men and women in a virtual Morris water task: A large and reliable sex difference. Behav. Brain Res 93, 185–190. - PubMed

[7] Astur RS, Taylor LB, Mamelak AN, Philpott L, Sutherland RJ, 2002. Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task. Behav. Brain Res 132, 77–84. - PubMed

[8] Astur RS, Taylor LB, Mamelak AN, Philpott L, Sutherland RJ, 2002. Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task. Behav. Brain Res 132, 77–84. - PubMed

[9] Astur RS, Tropp J, Sava S, Constable RT, Markus EJ, 2004. Sex differences and correlations in a virtual Morris water task, a virtual radial arm maze, and mental rotation. Behav. Brain Res 151, 103–115. - PubMed

[10] Astur RS, Tropp J, Sava S, Constable RT, Markus EJ, 2004. Sex differences and correlations in a virtual Morris water task, a virtual radial arm maze, and mental rotation. Behav. Brain Res 151, 103–115. - PubMed

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Relationships between drinking quantity and frequency and behavioral and hippocampal BOLD responses during working memory performance involving allocentric spatial navigation in college students

Affiliations

Relationships between drinking quantity and frequency and behavioral and hippocampal BOLD responses during working memory performance involving allocentric spatial navigation in college students

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