Diffusion Tensor Imaging of Brain Malformations: Exploring the Internal Architecture

Avner Meoded; Thierry A G M Huisman

doi:10.1016/j.nic.2019.03.004

Diffusion Tensor Imaging of Brain Malformations: Exploring the Internal Architecture

Neuroimaging Clin N Am. 2019 Aug;29(3):423-434. doi: 10.1016/j.nic.2019.03.004. Epub 2019 May 21.

Authors

Avner Meoded¹, Thierry A G M Huisman²

Affiliations

¹ Johns Hopkins All Children's Hospital, 501 6th Avenue South, St Petersburg, FL 33701, USA. Electronic address: ameoded1@jhmi.edu.
² Edward B. Singleton Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 470, Houston, TX 77030, USA.

PMID: 31256863
DOI: 10.1016/j.nic.2019.03.004

Abstract

Diffusion tensor imaging (DTI) is an advanced MR imaging technique that provides noninvasive qualitative and quantitative information about the white matter microarchitecture. By measuring the three-dimensional directional characteristics of water molecule diffusion/mobility, DTI generates unique tissue contrasts that are used to study the axonal organization of the central nervous system. Its applications include quantitative evaluation of the brain connectivity, development, and white matter diseases. This article reviews DTI and fiber tractography findings in several brain malformations and highlights the added value of DTI and fiber tractography compared with conventional MR imaging.

Keywords: Brain; Children; Diffusion tensor imaging; Fiber tractography; Magnetic resonance imaging; Malformations.

Publication types

Review

MeSH terms

Brain / abnormalities*
Brain / diagnostic imaging*
Diffusion Tensor Imaging / methods*
Humans