Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies

Nutrients. 2019 Jun 28;11(7):1479. doi: 10.3390/nu11071479.


Cerebrovascular accidents are currently the second major cause of death and the third leading cause of disability in the world, according to the World Health Organization (WHO), which has provided protocols for stroke prevention. Although there is a multitude of studies on the health benefits associated with anthocyanin (ACN) consumption, there is no a rigorous systematization of the data linking dietary ACN with stroke prevention. This review is intended to present data from epidemiological, in vitro, in vivo, and clinical studies dealing with the stroke related to ACN-rich diets or ACN supplements, along with possible mechanisms of action revealed by pharmacokinetic studies, including ACN passage through the blood-brain barrier (BBB).

Keywords: blood-brain-barrier; dietary anthocyanins; molecular mechanisms; stroke.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthocyanins / administration & dosage
  • Anthocyanins / pharmacokinetics*
  • Biological Availability
  • Biotransformation
  • Blood-Brain Barrier / metabolism
  • Capillary Permeability
  • Diet, Healthy*
  • Dietary Supplements* / adverse effects
  • Humans
  • Intestinal Absorption
  • Nutritive Value
  • Risk Factors
  • Stroke / diagnosis
  • Stroke / epidemiology
  • Stroke / prevention & control*


  • Anthocyanins