Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy

Nutrients. 2019 Jun 29;11(7):1492. doi: 10.3390/nu11071492.


Cow´s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow´s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow´s milk allergens. Here, we provide an overview about the allergen molecules in cow´s milk and the advantages of the molecular diagnosis of IgE sensitization to cow´s milk by serology. In addition, we review current strategies for prevention and treatment of cow´s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.

Keywords: Cow’s milk allergy; cow’s milk allergens; diagnosis of cow’s milk allergy; molecular diagnosis; prevention of cow’s milk allergy; treatment of cow’s milk allergy.

Publication types

  • Review

MeSH terms

  • Allergens*
  • Biomarkers / blood
  • Humans
  • Immunoglobulin E / blood*
  • Milk Hypersensitivity / diagnosis
  • Milk Hypersensitivity / immunology
  • Milk Hypersensitivity / prevention & control*
  • Milk Hypersensitivity / therapy*
  • Milk Proteins / adverse effects
  • Milk Proteins / immunology*
  • Molecular Diagnostic Techniques*
  • Phenotype
  • Predictive Value of Tests
  • Treatment Outcome


  • Allergens
  • Biomarkers
  • Milk Proteins
  • Immunoglobulin E