Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations

Trends Endocrinol Metab. 2019 Aug;30(8):557-567. doi: 10.1016/j.tem.2019.05.006. Epub 2019 Jun 28.


Ability to promote completion of mitotic cycling of adult mammalian cardiomyocytes remains an intractable and vexing challenge, despite being one of the most sought after 'holy grails' of cardiovascular research. While some of the struggle is attributable to adult cardiomyocytes themselves that are notoriously post-mitotic, another contributory factor rests with difficulty in definitive tracking of adult cardiomyocyte cell cycle and lack of rigorous measures to track proliferation in situ. This review summarizes past, present, and future directions to promote adult mammalian cardiomyocyte cell cycle progression, proliferation, and renewal. Establishing relationship(s) between cardiomyocyte cell cycle progression and cellular biological properties is sorely needed to understand the mechanistic basis for cardiomyocyte cell cycle withdrawal to enhance cardiomyocyte cell cycle progression and mitosis.

Keywords: cardiomyocyte; cell cycle; ploidy; proliferation; senescence.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics
  • Cell Cycle / physiology*
  • Cell Proliferation / genetics
  • Cell Proliferation / physiology*
  • Cellular Senescence / genetics
  • Cellular Senescence / physiology
  • Humans
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / metabolism