Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae

Nature. 1988 Mar 10;332(6160):173-6. doi: 10.1038/332173a0.


Benzylpenicillin has been used extensively for approximately 40 years in the treatment of gonorrhoea. The intense selective pressures resulting from the continual exposure of Neisseria gonorrhoeae to penicillin have resulted in the emergence of resistant strains that produce altered forms of penicillin-binding proteins (PBPs) with decreased affinity for the antibiotic. A comparison of the sequences of the PBP-2 genes from penicillin-sensitive and penicillin-resistant strains, suggests that penicillin-resistant forms of PBP 2 may have arisen both by amino-acid substitutions and insertions, and by the exchange of a region encoding part of the penicillin-sensitive transpeptidase domain with the homologous region from a closely related species.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyltransferases / genetics*
  • Amino Acid Sequence
  • Bacterial Proteins*
  • Base Sequence
  • Carrier Proteins*
  • Genes, Bacterial
  • Hexosyltransferases / genetics*
  • Molecular Sequence Data
  • Molecular Weight
  • Multienzyme Complexes / genetics*
  • Muramoylpentapeptide Carboxypeptidase*
  • Neisseria gonorrhoeae / drug effects*
  • Neisseria gonorrhoeae / genetics
  • Penicillin G / pharmacology*
  • Penicillin Resistance / genetics
  • Penicillin-Binding Proteins
  • Peptidyl Transferases / genetics*
  • Transformation, Bacterial


  • Bacterial Proteins
  • Carrier Proteins
  • Multienzyme Complexes
  • Penicillin-Binding Proteins
  • Acyltransferases
  • Peptidyl Transferases
  • Hexosyltransferases
  • Muramoylpentapeptide Carboxypeptidase
  • Penicillin G

Associated data

  • GENBANK/X07468
  • GENBANK/X07469
  • GENBANK/X07470
  • GENBANK/Y00303