Prognostic and predictive significance of KIT protein expression and c-kit gene mutation in canine cutaneous mast cell tumours: A consensus of the Oncology-Pathology Working Group

Vet Comp Oncol. 2019 Dec;17(4):451-455. doi: 10.1111/vco.12518. Epub 2019 Jul 9.


One of the primary objectives of the Oncology-Pathology Working Group (OPWG), a joint initiative of the Veterinary Cancer Society and the American College of Veterinary Pathologists, is for oncologists and pathologists to collaboratively generate consensus documents to standardize aspects of and provide guidelines for oncologic pathology. Consensus is established through critical review of peer-reviewed literature relevant to a subgroup's particular focus. Subsequent acceptance and approval of the document by the OPWG membership at large establishes consensus. The intent of this publication is to help educate practitioners and pathologists on the value of diagnostics related to the KIT receptor tyrosine kinase for canine cutaneous mast cell tumours and to provide a guide for the use of these tests in veterinary medicine. This document represents the opinions of the OPWG and the authors and does not constitute a formal endorsement by the American College of Veterinary Pathologists or the Veterinary Cancer Society.

Keywords: cancer; dog; immunohistochemistry; kinase; mutation.

Publication types

  • Review

MeSH terms

  • Animals
  • Dog Diseases / metabolism*
  • Dogs
  • Gene Expression Regulation, Neoplastic / physiology*
  • Mastocytoma / metabolism
  • Mastocytoma / veterinary*
  • Mutation
  • Proto-Oncogene Proteins c-kit / genetics
  • Proto-Oncogene Proteins c-kit / metabolism*
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / veterinary*


  • Proto-Oncogene Proteins c-kit