New oral liposomal vitamin C formulation: properties and bioavailability

J Liposome Res. 2020 Sep;30(3):227-234. doi: 10.1080/08982104.2019.1630642. Epub 2019 Jul 2.


Vitamin C is the exogenous compound necessary for a variety of metabolic processes; therefore, the efficient delivery is critical for the maintenance of body homeostasis. Vitamin C pharmacokinetics and low quantities in processed foodstuff, necessitates its continuous supplementation. In the paper, we present the new liposomal formulation of vitamin C free of harmful organic solvents. The formulation was quantitatively characterized with respect to its chemically composition and nano-structuring. The vitamin C accessibility to cells from the formulation was evaluated using evidence derived from experiments performed on cell cultures. Finally, the enhanced bioavailability of vitamin C from the formulation was demonstrated in the medical experiment.

Keywords: Liposome; bioavailability; efficacy; stability; vitamin C.

MeSH terms

  • Administration, Oral
  • Ascorbic Acid / administration & dosage*
  • Ascorbic Acid / chemistry
  • Ascorbic Acid / pharmacokinetics*
  • Biological Availability
  • Cell Survival / drug effects
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Drug Compounding
  • Humans
  • Liposomes


  • Liposomes
  • Ascorbic Acid