How Unavoidable Are Analytical Treatment Interruptions in HIV Cure-Related Studies?

J Infect Dis. 2019 Jul 2;220(220 Suppl 1):S24-S26. doi: 10.1093/infdis/jiz222.


In this discussion, 2 established researchers and clinical trialists debate their opposing views on the utility, benefits, and risks of the use of analytical interruption of antiretroviral therapy as a clinical trial end point and outcome measure in human studies seeking to induce remission of or eradicate human immunodeficiency virus infection.

Keywords: Analytical treatment interruption; antiretroviral therapy; viral outgrowth assay.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Coinfection / prevention & control*
  • Female
  • HIV Infections / prevention & control*
  • HIV Infections / transmission*
  • Humans
  • Male
  • Risk Factors
  • Vaccines / administration & dosage*
  • Withholding Treatment*


  • Anti-HIV Agents
  • Vaccines