Management of ovarian hyperstimulation syndrome with chlorpheniramine maleate, mannitol, and invasive hemodynamic monitoring

Obstet Gynecol. 1988 Mar;71(3 Pt 2):485-7.


Ovarian hyperstimulation syndrome due to exogenous gonadotropin administration is life-threatening in its most severe form. Profound fluid shifts may occur, with concomitant cardiovascular changes. We present a case of severe ovarian hyperstimulation syndrome managed with chlorpheniramine maleate (previously shown to be effective in animal models) and invasive hemodynamic monitoring. Mannitol and albumin infusions were also used to maintain urine output and intravascular volume.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chlorpheniramine / therapeutic use*
  • Female
  • Fertilization in Vitro
  • Gonadotropins / adverse effects*
  • Hemodynamics
  • Humans
  • Mannitol / therapeutic use*
  • Monitoring, Physiologic
  • Ovarian Diseases / chemically induced
  • Ovarian Diseases / drug therapy*
  • Ovulation Induction
  • Syndrome


  • Gonadotropins
  • Mannitol
  • Chlorpheniramine