Acyl Radicals from Benzothiazolines: Synthons for Alkylation, Alkenylation, and Alkynylation Reactions

Lei Li; Shan Guo; Qi Wang; Jin Zhu

doi:10.1021/acs.orglett.9b01717

Acyl Radicals from Benzothiazolines: Synthons for Alkylation, Alkenylation, and Alkynylation Reactions

Org Lett. 2019 Jul 19;21(14):5462-5466. doi: 10.1021/acs.orglett.9b01717. Epub 2019 Jul 2.

Authors

Lei Li¹, Shan Guo¹, Qi Wang¹, Jin Zhu¹

Affiliation

¹ Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Chemistry for Life Sciences , Nanjing University , Nanjing 210023 , China.

PMID: 31264884
DOI: 10.1021/acs.orglett.9b01717

Abstract

We describe herein a fundamentally new visible light-driven homolytic C-C bond breaking mode for the generation of acyl radicals from C2-acyl-substituted benzothiazolines. The reactive species can be used as versatile synthons for formal radical alkylation, alkenylation, and alkynylation reactions.