Neuroprotective Potential of Ginkgo biloba in Retinal Diseases

Planta Med. 2019 Nov;85(17):1292-1303. doi: 10.1055/a-0947-5712. Epub 2019 Jul 2.


Like other tissues of the central nervous system, the retina is susceptible to damage by oxidative processes that result in several neurodegenerative disease such as age-related macular degeneration, diabetic retinopathy, glaucoma, ischaemic retinal disease, retinal disease produced by light oxidation, and detached retina, among other diseases. The use of antioxidant substances is a solution to some health problems caused by oxidative stress, because they regulate redox homeostasis and reduce oxidative stress. This is important for neurodegeneration linked to oxidation processes. In line with this, Ginkgo biloba is a medicinal plant with excellent antioxidant properties whose effects have been demonstrated in several degenerative processes, including retinal diseases associated with neurodegeneration. This review describes the current literature on the role of ginkgo in retinal diseases associated with neurodegeneration. The information leads to the conclusion that G. biloba extracts might be a good option to improve certain neurodegenerative retinal diseases, but more research is needed to determine the safety and efficacy of G. biloba in these retinal degenerative processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Ginkgo biloba / chemistry*
  • Humans
  • Neurodegenerative Diseases / complications
  • Neuroprotective Agents / therapeutic use*
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Retinal Diseases / drug therapy*
  • Retinal Diseases / etiology


  • Neuroprotective Agents
  • Plant Extracts
  • Ginkgo biloba extract