Global Perspective on Hepatitis B Virus Infections in the Era of Effective Vaccines

Clin Liver Dis. 2019 Aug;23(3):383-399. doi: 10.1016/j.cld.2019.04.001. Epub 2019 May 23.

Abstract

Hepatitis B virus (HBV) infection is a global health burden. The chronicity of this infection leads to complication such as cirrhosis and hepatocellular carcinoma, making it a leading cause of morbidity and mortality worldwide. Chronic infection commonly develops among those who acquire infection during childhood, hence the importance of effective implementation of HBV vaccination policies designed to eradicate chronic HBV. This article provides updated estimates of worldwide HBV disease prevalence and discusses how implementation of vaccination policies has affected HBV epidemiology.

Keywords: Birth dose vaccine; Global prevalence; Hepatitis B; Seroprevalence; Vaccination; Vaccine implementation.

Publication types

  • Review

MeSH terms

  • Communicable Disease Control / organization & administration*
  • Female
  • Global Health*
  • Hepatitis B / epidemiology*
  • Hepatitis B / physiopathology
  • Hepatitis B / prevention & control*
  • Hepatitis B Vaccines / administration & dosage*
  • Hepatitis B, Chronic / epidemiology
  • Hepatitis B, Chronic / physiopathology
  • Hepatitis B, Chronic / prevention & control
  • Humans
  • Male
  • Prevalence
  • Program Evaluation
  • Risk Assessment
  • Survival Analysis
  • Vaccination / statistics & numerical data*

Substances

  • Hepatitis B Vaccines