Abstract
The nucleotide sequence of PSE-2 beta-lactamase, an enzyme that readily hydrolyzes both carbenicillin and oxacillin, has been determined. The deduced sequence of 266 amino acids contained 93 residues identical to those of OXA-2 beta-lactamase and the Ser-Thr-Phe-Lys tetrad also found in the active site of TEM-1 beta-lactamase.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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DNA, Bacterial / genetics
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Genes, Bacterial*
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Molecular Sequence Data
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Pseudomonas aeruginosa / genetics*
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Sequence Homology, Nucleic Acid
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beta-Lactamases / genetics*
Substances
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DNA, Bacterial
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beta-lactamase PSE-2
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beta-Lactamases