Fuchs endothelial corneal dystrophy (FECD) is amongst one of the most common indications for endothelial keratoplasty worldwide. Despite being originally described among Caucasians, it is now known to be prevalent among a large number of populations, including Asians. While the FECD phenotype is classically described as that of central guttate and pigment deposits associated with corneal endothelial dysfunction, there are subtle yet important differences in how FECD and its phenocopies may present in Caucasians vs Asians. Such differences are paralled by genotypic variations and disease management preferences which appear to be geographically and ethnically delineated. This article provides a succinct review of such differences, with a focus on diagnostic and management issues which may be encountered by ophthalmologists practicing in the different geographic regions, when evaluating a patient with FECD.
摘要: 在全球范围内, Fuchs角膜内皮营养不良 (FECD) 是角膜内皮移植术最常见的适应症之一。尽管FECD最早报道于高加索人, 但目前已在包括亚洲人在内的人群中广泛流行。 FECD的典型临床表现是与角膜内皮细胞营养不良相关的中心斑点和色素沉着, 然而FECD和其拟表型在高加索人种和亚洲人种中的表现可能有细微但重要的差别。这些差别与基因多态性及与疾病管理的首选方式随区域和种族的不同相关。本篇文章简短地回顾了这些差别, 重点强调当眼科医生在不同地区面对FECD患者时, 诊断与管理方面的问题。.