A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System

Cell Metab. 2019 Jul 2;30(1):14-15. doi: 10.1016/j.cmet.2019.06.012.


Ferroptosis is a form of regulated cell death involving lethal peroxidation of phospholipids (Hirschhorn and Stockwell, 2019). Recent results reveal that ferroptosis mediates the tumor suppressive activity of interferon gamma secreted by CD8+ T cells in response to immune checkpoint blockade, suggesting the immune system may function in part through ferroptosis to prevent tumorigenesis (Wang et al., 2019).

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • CD8-Positive T-Lymphocytes*
  • Ferroptosis
  • Humans
  • Immunotherapy
  • Iron
  • Neoplasms*


  • Iron