A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

Cell. 1988 Apr 8;53(1):37-43. doi: 10.1016/0092-8674(88)90485-0.


Egr-1 is an early growth response gene that displays fos-like induction kinetics in fibroblasts, epithelial cells, and lymphocytes following mitogenic stimulation. Sequence analysis of murine Egr-1 cDNA predicts a protein with three DNA binding zinc fingers. The human EGR1 gene maps to chromosome 5 (bands 5q23-31). Egr-1 mRNA increases dramatically during cardiac and neural cell differentiation, and following membrane depolarization both in vitro and in vivo. Thus, Egr-1 and c-fos are often coregulated with strikingly similar kinetics. These results, in conjunction with the Egr-1 primary structure, suggest that Egr-1 may function as a transcriptional regulator in diverse biological processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Differentiation
  • Cell Division
  • Cells, Cultured
  • Chromosome Mapping
  • Chromosomes, Human, Pair 5
  • DNA-Binding Proteins / genetics*
  • Genes*
  • Genes, Regulator*
  • Humans
  • Kinetics
  • Metalloproteins / genetics*
  • Molecular Sequence Data
  • Protein Binding
  • Proto-Oncogenes*
  • Zinc / metabolism


  • DNA-Binding Proteins
  • Metalloproteins
  • Zinc

Associated data

  • GENBANK/M20157