The research of ion channel-related gene polymorphisms with atrial fibrillation in the Chinese Han population

Mol Genet Genomic Med. 2019 Aug;7(8):e835. doi: 10.1002/mgg3.835. Epub 2019 Jul 4.


Background: Atrial fibrillation (AF) is one of the common arrhythmia in clinics. Its incidence is high among the elderly. This study aimed to identify a possible connection between ion channel-related gene polymorphisms and the risk of AF.

Methods: A total of 381 patients with coronary heart disease were recruited. Based on complete cardiac examination, the patients were divided into two subgroups: 185 patients with AF and 196 patients without AF. An association analysis was performed using 13 genotyped SNPs. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by conditional logistic regression.

Results: In our research, we found that KCNE2 rs8134775 was associated with a decreased AF risk in the allele model (OR = 0.70; 95% CI: 0.50-0.97; p = 0.034). Genetic model analysis shown that the minor allele T of GJA5 rs35594137 was associated with a decreased AF risk under the recessive model (OR = 0.40; 95% CI: 0.19-0.86; p = 0.018) and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive model (OR = 2.31; 95% CI: 1.20-4.42; p = 0.012).

Conclusions: Our results suggest that KCNE2, KCNJ2, and GJA5 influence the development of AF.

Keywords: atrial fibrillation (AF); case-control study; single nucleotide polymorphism (SNP).

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Asian People / genetics
  • Atrial Fibrillation / blood
  • Atrial Fibrillation / diagnosis
  • Atrial Fibrillation / genetics*
  • Case-Control Studies
  • Connexins / genetics*
  • Coronary Disease / blood
  • Coronary Disease / complications*
  • Coronary Disease / genetics
  • Female
  • Gap Junction alpha-5 Protein
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotyping Techniques
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic
  • Polymorphism, Single Nucleotide
  • Potassium Channels, Inwardly Rectifying / genetics*
  • Potassium Channels, Voltage-Gated / genetics*


  • Connexins
  • KCNE2 protein, human
  • KCNJ2 protein, human
  • Potassium Channels, Inwardly Rectifying
  • Potassium Channels, Voltage-Gated