Filling a gYap in Hepato-Biliary Tissue Integration in Liver Homeostasis and Regeneration

Tohru Itoh; Atsushi Miyajima

doi:10.1016/j.stem.2019.06.006

Filling a gYap in Hepato-Biliary Tissue Integration in Liver Homeostasis and Regeneration

Cell Stem Cell. 2019 Jul 3;25(1):5-6. doi: 10.1016/j.stem.2019.06.006.

Authors

Tohru Itoh¹, Atsushi Miyajima²

Affiliations

¹ Laboratory of Stem Cell Therapy, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan. Electronic address: itohru@iam.u-tokyo.ac.jp.
² Laboratory of Stem Cell Therapy, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan. Electronic address: miyajima@iam.u-tokyo.ac.jp.

PMID: 31271747
DOI: 10.1016/j.stem.2019.06.006

Abstract

Liver bile ducts serve primarily as drainage for bile and undergo extensive remodeling in response to hepatocyte injuries. In this issue of Cell Stem Cell, Pepe-Mooney et al. (2019) and Planas-Paz et al. (2019) show that Yap signaling can be activated by bile acids and is critical for biliary tissue homeostasis and dynamics.

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MeSH terms

Biliary Tract*
Homeostasis
Liver
Liver Regeneration
Single-Cell Analysis*