Crohn's Disease and the Risk of Cancer

Clin Colon Rectal Surg. 2019 Jul;32(4):305-313. doi: 10.1055/s-0039-1683923. Epub 2019 Jul 2.


Crohn's disease is associated with various intestinal and extraintestinal malignancies. This article reviews the current literature regarding Crohn's disease and subsequent risk of cancer formation. Recognition of risk factors (both modifiable and unmodifiable) is essential for prevention and appropriate screening. Future investigations into the molecular mechanisms associated with Crohn-related malignancy will provide additional insight into carcinogenesis, potential for early intervention, and identification of at-risk patients.

Keywords: Crohn's disease; cancer; inflammatory bowel disease; malignancy.

Publication types

  • Review