Does serum gastric parietal cell antibody titer have influence on anemia and vitamin B12 deficiency in atrophic glossitis patients?

J Formos Med Assoc. 2020 Jan;119(1 Pt 2):377-383. doi: 10.1016/j.jfma.2019.06.009. Epub 2019 Jul 2.

Abstract

Background/purpose: Our previous study found 284 gastric parietal cell antibody (GPCA)-positive atrophic glossitis (AG) patients (so-called GPCA+AG patients in this study) in a group of 1064 AG patients. This study evaluated whether high-titer (GPCA titer ≥ 160) GPCA+AG patients had greater frequencies of anemia, vitamin B12 deficiency, macrocytosis, and hyperhomocysteinemia than low-titer (GPCA titer < 160) GPCA+AG patients.

Methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 117 high-titer GPCA+AG patients, 167 low-titer GPCA+AG patients, and 532 healthy control subjects were measured and compared.

Results: We found that 12.0%, 29.1%, 23.1%, 16.2%, 1.7%, and 23.1% of 117 high-titer GPCA+AG patients and 5.4%, 17.4%, 17.4%, 7.2%, 1.2%, and 14.4% of 167 low-titer GPCA+AG patients were diagnosed as having macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. Moreover, both 117 high-titer and 167 low-titer GPCA+AG patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than 532 healthy control subjects (all P-values < 0.05). In addition, 117 high-titer GPCA+AG patients also had greater frequencies of anemia (P = 0.029, statistically significant), serum vitamin B12 deficiency (P = 0.027, statistically significant), macrocytosis (P = 0.075, marginal significance), and hyperhomocysteinemia (P = 0.085, marginal significance) than 167 low-titer GPCA+AG patients.

Conclusion: For GPCA+AG patients, high-titer GPCA+AG patients have greater frequencies of anemia, serum vitamin B12 deficiency, macrocytosis, and hyperhomocysteinemia than low-titer GPCA+AG patients.

Keywords: Anemia; Atrophic glossitis; Gastric parietal cell antibody; Hyperhomocysteinemia; Vitamin B12.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anemia, Macrocytic / blood*
  • Anemia, Macrocytic / complications
  • Anemia, Macrocytic / immunology
  • Atrophy
  • Autoantibodies / blood*
  • Case-Control Studies
  • Erythrocyte Indices
  • Female
  • Folic Acid / blood
  • Glossitis / blood*
  • Glossitis / complications
  • Glossitis / immunology
  • Hemoglobins / analysis
  • Homocysteine / blood
  • Humans
  • Hyperhomocysteinemia / etiology*
  • Iron / blood
  • Male
  • Middle Aged
  • Parietal Cells, Gastric / immunology
  • Tongue / pathology
  • Vitamin B 12 / blood
  • Vitamin B 12 Deficiency / blood*
  • Vitamin B 12 Deficiency / complications

Substances

  • Autoantibodies
  • Hemoglobins
  • Homocysteine
  • Folic Acid
  • Iron
  • Vitamin B 12