Highlights of aliphatic C(sp3 )-H hydrogen isotope exchange reactions

Mégane Valero; Volker Derdau

doi:10.1002/jlcr.3783

Highlights of aliphatic C(sp³ )-H hydrogen isotope exchange reactions

J Labelled Comp Radiopharm. 2020 May 30;63(6):266-280. doi: 10.1002/jlcr.3783. Epub 2019 Aug 19.

Authors

Mégane Valero¹, Volker Derdau¹

Affiliation

¹ R&D, Integrated Drug Discovery, Isotope Chemistry, Sanofi Germany, Frankfurt, Germany.

PMID: 31278771
DOI: 10.1002/jlcr.3783

Abstract

This review summarizes the highlights of aliphatic C (sp³ )-H carbon hydrogen isotope exchange (HIE) methods developed in the last 10 years. In particular, new highly selective and reactive protocols in the areas of nanoparticle and metal-catalyzed homogeneous catalysis are reported.

Keywords: catalysis; deuterium; hydrogen isotope exchange; tritium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Hydrogen / chemistry*
Isotopes / chemistry*

Substances

Isotopes
Hydrogen