Background: Some genetic association studies tried to investigate potential associations of phosphatase and actin regulator 1 (PHACTR1) polymorphisms with coronary artery disease (CAD). However, the results of these studies were not consistent. Thus, we performed the present meta-analysis to explore associations between PHACTR1 polymorphisms and CAD in a larger pooled population.
Methods: Systematic literature research of PubMed, Web of Science, Embase and CNKI was performed to identify eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate strength of associations.
Results: Totally 8 studies were included for analyses (10856 cases and 18801 controls). Pooled analyses suggested that rs9349379 polymorphism was significantly associated with CAD in overall population (dominant model: p=0.004, OR=1.39, 95%CI 1.11-1.73, I2 =91%; recessive model: p=0.002, OR=0.63, 95%CI 0.48-0.84, I2 =85%; over-dominant model: p=0.03, OR=0.89, 95%CI 0.80-0.99, I2 =59%; allele model: p=0.0002, OR=1.30, 95%CI 1.13-1.49, I2 =89%), and this significant finding was further confirmed in both Asians and Caucasians. However, no any positive findings were observed for rs2026458 polymorphism in pooled analyses.
Conclusions: Our meta-analysis suggested that rs9349379 polymorphism might affect individual susceptibility to CAD in both Caucasians and Asians. Future investigations need to explore the underlying molecular mechanisms of our positive findings.
Keywords: Coronary artery disease (CAD); Meta-analysis; Phosphatase and actin regulator 1 (PHACTR1); Polymorphisms.
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