The Prognostic Value of Late Gadolinium Enhancement in Nonischemic Heart Disease

Zorana Mrsic; Negareh Mousavi; Edward Hulten; Marcio Sommer Bittencourt

doi:10.1016/j.mric.2019.04.010

The Prognostic Value of Late Gadolinium Enhancement in Nonischemic Heart Disease

Magn Reson Imaging Clin N Am. 2019 Aug;27(3):545-561. doi: 10.1016/j.mric.2019.04.010.

Authors

Zorana Mrsic¹, Negareh Mousavi², Edward Hulten³, Marcio Sommer Bittencourt⁴

Affiliations

¹ Department of Cardiology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, MD 20814, USA; Uniformed Services University School of Health Sciences, Bethesda, MD, USA.
² McGill University Health Centre, Royal Victoria Hospital, 1001 Decarie Boulevard, D05.5115, Montreal, Quebec H4A 3J1, Canada.
³ Uniformed Services University School of Health Sciences, Bethesda, MD, USA; Cardiopulmonary Clinic, Department of Medicine, Evans Army Community Hospital, 1650 Cochrane Circle, Fort Carson, CO 80913, USA.
⁴ Delboni - DASA, São Paulo, Brazil; Hospital Israelita Albert Einstein & School of Medicine, Faculdade Israelita de Ciência da Saúde Albert Einstein, São Paulo, Brazil; Center for Clinical and Epidemiological Research, University Hospital & Sao Paulo State Cancer Institute, University of Sao Paulo, Av. Lineu Prestes, 2565 - Butanta, São Paulo 05412-003, Brazil. Electronic address: mbittencourt@hu.usp.br.

PMID: 31279456
DOI: 10.1016/j.mric.2019.04.010

Abstract

Late gadolinium enhancement (LGE) has become a standard clinical tool to evaluate myocardial fibrosis to define myocardial viability in the context of ischemic myocardial disease. More recently, LGE has also been used to characterize the presence and pattern of fibrosis in nonischemic cardiomyopathies. It yields unique and valuable diagnostic and prognostic insights for myriad nonischemic clinical indications and has become a key part of routine cardiac MR imaging, and a tool to guide treatment. This article reviews the technical aspects of LGE performance and its diagnostic and prognostic implications in nonischemic cardiomyopathy.

Keywords: Diagnosis; Late gadolinium enhancement; Myocardial disease; Nonischemic myocardial disease; Prognosis.

Publication types

Review

MeSH terms

Contrast Media / pharmacokinetics*
Gadolinium / pharmacokinetics*
Heart Diseases / diagnostic imaging*
Humans
Image Enhancement / methods*
Magnetic Resonance Imaging / methods*
Prognosis
Reproducibility of Results

Substances

Contrast Media
Gadolinium