Activity of some naphthoquinones on blood stream forms of Trypanosoma cruzi

A V Pinto; V F Ferreira; R S Capella; B Gilbert; M C Pinto; J S da Silva

doi:10.1016/0035-9203(87)90427-5

Activity of some naphthoquinones on blood stream forms of Trypanosoma cruzi

Trans R Soc Trop Med Hyg. 1987;81(4):609-10. doi: 10.1016/0035-9203(87)90427-5.

Authors

A V Pinto¹, V F Ferreira, R S Capella, B Gilbert, M C Pinto, J S da Silva

Affiliation

¹ Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Brazil.

PMID: 3127962
DOI: 10.1016/0035-9203(87)90427-5

Abstract

Accidental transmission of Chagas disease to man by blood transfusion is a serious problem in Latin America. This paper describes the testing of several naphthoquinones, some of which were active against blood trypomastigotes in vitro at 4 degrees C and might therefore warrant further study for preventing transmission of Chagas disease by blood transfusion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Transfusion
Chagas Disease / prevention & control
Chagas Disease / transmission
Humans
Naphthoquinones / pharmacology*
Structure-Activity Relationship
Trypanosoma cruzi / drug effects*

Substances

Naphthoquinones