Intraoperative Parathyroid Hormone Monitoring in Parathyroidectomy for Tertiary Hyperparathyroidism

J Surg Res. 2019 Dec;244:77-83. doi: 10.1016/j.jss.2019.06.020. Epub 2019 Jul 4.

Abstract

Background: Tertiary hyperparathyroidism (THPT) is characterized by hypercalcemia and hyperparathyroidism after renal allograft. Limited data exist regarding the use of intraoperative parathyroid hormone (IOPTH) for THPT. We examined our series of parathyroidectomies performed for THPT to determine clinical outcomes with respect to IOPTH.

Materials and methods: Patients who underwent parathyroidectomy for THPT (1999-2017) were identified for inclusion. Retrospective chart review was performed. Cure was defined as eucalcemia ≥6 mo after surgery. Statistical analysis was performed.

Results: Of 41 patients included in the study, 41% (n = 17) were female. The median duration of dialysis before renal allograft was 34 mo (interquartile interval [IQI]:6-60). Preoperatively, the median calcium level was 10.4 mg/dL (IQI:10.0-11.2), median parathyroid hormone was 172 pg/mL (IQI:104-293), and renal function was minimally abnormal with median glomerular filtration rate 58 mL/min/1.73 m2 (IQI:49-71). At surgery, the median final IOPTH was 40 pg/mL (IQI:29-73), and median decrease in IOPTH was 78% (IQI:72-87), with 88% (n = 36) of patients demonstrating >50% decrease. Median calcium level ≥6 mo after surgery was 9.4 mg/dL (IQI:8.8-9.7), and only one patient had recurrent hypercalcemia. Failure to achieve >50% decrease in IOPTH was not significantly associated with recurrent hypercalcemia (P = 1.000). With a median follow-up time of 41 mo (IQI:25-70), only three patients had graft failure. The positive predictive value of IOPTH for cure was 89% (95% confidence interval: 0.752-0.971), with 0% negative predictive value and 87% accuracy (95% confidence interval: 0.726-0.957).

Conclusions: Subtotal parathyroidectomy is a successful operation with durable cure of THPT. IOPTH fails to predict long-term cure in THPT despite minimally abnormal renal function.

Keywords: IOPTH; Intraoperative parathyroid hormone monitoring; PTH; Parathyroid; Parathyroidectomy; Tertiary hyperparathyroidism.

MeSH terms

  • Aftercare
  • Aged
  • Calcium / blood
  • Feasibility Studies
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Hypercalcemia / blood
  • Hypercalcemia / etiology
  • Hypercalcemia / surgery*
  • Hyperparathyroidism / blood
  • Hyperparathyroidism / etiology
  • Hyperparathyroidism / surgery*
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Monitoring, Intraoperative / methods*
  • Parathyroid Glands / metabolism
  • Parathyroid Glands / surgery
  • Parathyroid Hormone / blood*
  • Parathyroid Hormone / metabolism
  • Parathyroidectomy / methods*
  • Predictive Value of Tests
  • Recurrence
  • Retrospective Studies
  • Time Factors

Substances

  • Parathyroid Hormone
  • Calcium