Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

In Vivo. 2019 Jul-Aug;33(4):1313-1324. doi: 10.21873/invivo.11605.


Multiple primary malignant neoplasms are multiple tumors with different pathogenetic origin. They may be synchronous or metachronous. The management of these conditions represents an interesting clinical scenario. A crucial aspect is the decision regarding which tumor to treat initially, and how to schedule further treatments according to individual tumor risk. This process involves a multidisciplinary physician team to ensure favorable outcomes. We describe a case report of a female patient affected by primary synchronous tumors of the breast and pectoral skin, which raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature.

Keywords: Breast cancer; multiple primary malignant neoplasms; review; solid tumors.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biopsy
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / therapy*
  • Female
  • Humans
  • Mammaplasty / adverse effects
  • Mammaplasty / methods
  • Mammography
  • Mastectomy / adverse effects
  • Mastectomy / methods
  • Neoplasms, Multiple Primary / diagnosis*
  • Neoplasms, Multiple Primary / etiology
  • Neoplasms, Multiple Primary / therapy*
  • Neoplasms, Second Primary / diagnosis*
  • Neoplasms, Second Primary / etiology
  • Neoplasms, Second Primary / therapy*
  • Postoperative Complications
  • Symptom Assessment
  • Treatment Outcome