Exposure to bisphenol A and diabetes risk in Mexican women

Environ Sci Pollut Res Int. 2019 Sep;26(25):26332-26338. doi: 10.1007/s11356-019-05731-9. Epub 2019 Jul 9.

Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the production of polycarbonate plastics and epoxy resins, which has been previously linked to diabetes among non-Hispanic populations. As part of a case control study for breast cancer, only controls with BPA information were included in this report. The final sample size comprises 70 self-reported diabetics and 334 non-diabetics. Urinary free bisphenol A (BPA-F) (μg/L) was determined by solid-phase extraction and HPLC/FLD analysis. Logistic regression models were used to evaluate the association between BPA-F and self-reported diabetes. After adjusting by age, urinary BPA-F (4.06-224.53 μg/g creatinine) was associated with diabetes exposure (OR = 1.85; 95% CI 1.04, 3.28) compared with women in the reference category (0.67-4.05 μg/g creatinine). BPA may be an environmental cofactor of diabetes. More studies are needed to confirm this result, especially in Hispanic populations.

Keywords: BPA; Bisphenol a; Diabetes; Endocrine-disrupting chemical; Mexico; Women.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Benzhydryl Compounds / toxicity*
  • Benzhydryl Compounds / urine
  • Case-Control Studies
  • Creatinine / urine
  • Diabetes Mellitus / chemically induced*
  • Diabetes Mellitus / urine
  • Endocrine Disruptors / toxicity
  • Endocrine Disruptors / urine
  • Environmental Exposure / adverse effects*
  • Female
  • Humans
  • Mexico
  • Middle Aged
  • Phenols / toxicity*
  • Phenols / urine
  • Risk Factors

Substances

  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • Creatinine
  • bisphenol A