Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir 1

Emerg Infect Dis. 2019 Oct;25(10):1969-1972. doi: 10.3201/eid2510.190607. Epub 2019 Oct 17.

Abstract

Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2-98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors.

Keywords: H7N9; United States; avian influenza; baloxavir; baloxavir marboxil; drug susceptibility; highly pathogenic viruses; influenza viruses; pandemic potential; respiratory infections; viruses; zoonoses; zoonotic influenza.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Chickens / virology
  • Dibenzothiepins
  • Dogs
  • Humans
  • Influenza A virus / drug effects*
  • Influenza B virus / drug effects*
  • Influenza in Birds / drug therapy
  • Influenza in Birds / virology
  • Influenza, Human / drug therapy
  • Influenza, Human / virology
  • Influenzavirus C / drug effects*
  • Madin Darby Canine Kidney Cells / virology
  • Microbial Sensitivity Tests
  • Morpholines
  • Orthomyxoviridae Infections / drug therapy
  • Orthomyxoviridae Infections / veterinary
  • Orthomyxoviridae Infections / virology
  • Oxazines / pharmacology*
  • Pyridines / pharmacology*
  • Pyridones
  • Swine / virology
  • Swine Diseases / drug therapy
  • Swine Diseases / virology
  • Thiepins / pharmacology*
  • Thogotovirus / drug effects*
  • Triazines / pharmacology*

Substances

  • Antiviral Agents
  • Dibenzothiepins
  • Morpholines
  • Oxazines
  • Pyridines
  • Pyridones
  • Thiepins
  • Triazines
  • baloxavir