Perspectives on the role of Wnt biology in cancer

Sci Signal. 2019 Jul 9;12(589):eaay4494. doi: 10.1126/scisignal.aay4494.

Abstract

Selected members of the Wnt signaling community met during a 4-day period in October 2018 to discuss the current challenges and opportunities associated with targeting the Wnt pathway for therapeutic benefit. A summary of key points of these discussions is presented in this report.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyltransferases / antagonists & inhibitors
  • Acyltransferases / metabolism
  • Antineoplastic Agents / therapeutic use*
  • Enzyme Inhibitors / therapeutic use
  • Humans
  • Membrane Proteins / antagonists & inhibitors
  • Membrane Proteins / metabolism
  • Molecular Targeted Therapy / methods*
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Tankyrases / antagonists & inhibitors
  • Tankyrases / metabolism
  • Wnt Signaling Pathway / drug effects*
  • beta Catenin / antagonists & inhibitors*
  • beta Catenin / metabolism

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Membrane Proteins
  • beta Catenin
  • Acyltransferases
  • PORCN protein, human
  • Tankyrases