Abstract
We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Cell Proliferation / drug effects
-
Cell Survival / drug effects
-
Dose-Response Relationship, Drug
-
Drug Screening Assays, Antitumor
-
Glucuronides / chemical synthesis*
-
Glucuronides / chemistry
-
Glucuronides / pharmacology
-
HeLa Cells
-
Humans
-
Molecular Structure
-
Prodrugs / chemical synthesis*
-
Prodrugs / chemistry
-
Prodrugs / pharmacology
-
Structure-Activity Relationship
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Glucuronides
-
Prodrugs