mSphere of Influence: Adenosine in Host Defense against Bacterial Pneumonia-Friend or Foe?

mSphere. 2019 Jul 10;4(4):e00326-19. doi: 10.1128/mSphere.00326-19.


Elsa N. Bou Ghanem works in the field of innate immune senescence, inflammation, and host defense. In this mSphere of Influence article, she reflects on how "Adenosine A2B receptor deficiency promotes host defenses against Gram-negative bacterial pneumonia" by Barletta et al. (K. E. Barletta, R. E. Cagnina, M. D. Burdick, J. Linden, and B. Mehrad, Am J Respir Crit Care Med 186:1044-1050, 2012, impacted her own work examining the role of the extracellular adenosine pathway in neutrophil responses and host defense against pneumococcal pneumonia.

Keywords: CD73; Streptococcus pneumoniae; bacterial pneumonia; extracellular adenosine; inflammation; lung infection; neutrophils.

Publication types

  • Personal Narrative
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Host-Pathogen Interactions*
  • Lung / microbiology
  • Mice
  • Neutrophils / immunology*
  • Pneumonia, Bacterial / immunology*
  • Pneumonia, Pneumococcal / immunology*
  • Receptor, Adenosine A2B / deficiency
  • Receptor, Adenosine A2B / immunology*
  • Streptococcus pneumoniae / immunology


  • Receptor, Adenosine A2B