Cycloartenyl Ferulate and β-Sitosteryl Ferulate - Steryl Ferulates of γ-Oryzanol - Suppress Intracellular Reactive Oxygen Species in Cell-based System

J Oleo Sci. 2019 Aug 1;68(8):765-768. doi: 10.5650/jos.ess19054. Epub 2019 Jul 10.


γ-Oryzanol is a naturally occurring component of rice bran and consists of various steryl ferulates. The antioxidant activities of γ-oryzanol have mostly been demonstrated in cell-free systems. Therefore, we determined whether steryl ferulate of γ-oryzanol suppress spontaneous intracellular reactive oxygen species (ROS) in cell-based systems. We found that cycloartenyl ferulate and β-sitosteryl ferulate suppressed spontaneous intracellular ROS in a similar way to N-acetylcysteine and α-tocopherol.

Keywords: cycloartenyl ferulate; intracellular reactive oxygen species; β-sitosteryl ferulate; γ-oryzanol.

MeSH terms

  • Antioxidants / pharmacology*
  • Bridged-Ring Compounds / pharmacology*
  • Coumaric Acids / pharmacology*
  • HT29 Cells
  • Humans
  • Phenylpropionates / pharmacology*
  • Reactive Oxygen Species / metabolism*
  • Sitosterols / pharmacology*


  • Antioxidants
  • Bridged-Ring Compounds
  • Coumaric Acids
  • Phenylpropionates
  • Reactive Oxygen Species
  • Sitosterols
  • beta-sitosteryl ferulate
  • cycloartenyl ferulate
  • gamma-oryzanol