Relationship Between Constipation and Medication

J UOEH. 2019;41(2):145-151. doi: 10.7888/juoeh.41.145.


Constipation is very common and can be caused by adverse drug reactions as a result of many drugs. While the adverse effects of several medications such as opioids and anticholinergic agents are well established and well known, other commonly prescribed drugs, such as hypnotics, are less well understood. This review presents the results of an analysis of the relationship between constipation and drugs.

Keywords: adverse drug reaction; anticholinergic agent; constipation; hypnotic; opioid.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anticonvulsants / adverse effects
  • Antidepressive Agents, Tricyclic / adverse effects
  • Calcium Channel Blockers / adverse effects
  • Cholinergic Antagonists / adverse effects*
  • Constipation / chemically induced*
  • Diuretics / adverse effects
  • Histamine Antagonists / adverse effects
  • Humans
  • Hypnotics and Sedatives / adverse effects*
  • Opioid-Induced Constipation / etiology
  • Parasympatholytics / adverse effects


  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants
  • Antidepressive Agents, Tricyclic
  • Calcium Channel Blockers
  • Cholinergic Antagonists
  • Diuretics
  • Histamine Antagonists
  • Hypnotics and Sedatives
  • Parasympatholytics