A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells

EMBO J. 1988 Jan;7(1):29-35.

Abstract

Zinc fingers are DNA-binding domains present in several eukaryotic regulatory proteins. We have identified a mouse gene, Krox-20, encoding a protein with three zinc fingers and whose expression is activated during G0/G1 transition in cultured cells. Serum stimulation of quiescent cells leads to rapid and transient accumulation of Krox-20 mRNA, with kinetics similar to those of the c-fos proto-oncogene. The induction does not require de-novo protein synthesis. In the mouse, Krox-20 is expressed at low levels in tissues which contain rapidly dividing cells. These properties suggest that Krox-20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cells, Cultured
  • Cloning, Molecular
  • DNA / genetics
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism*
  • Early Growth Response Protein 2
  • Gene Expression Regulation*
  • Genes*
  • Interphase*
  • Metalloproteins / genetics*
  • Mice
  • Mice, Inbred Strains
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Transcription Factors / genetics*
  • Zinc

Substances

  • DNA-Binding Proteins
  • Early Growth Response Protein 2
  • Egr2 protein, mouse
  • Metalloproteins
  • Transcription Factors
  • DNA
  • Zinc

Associated data

  • GENBANK/X06746