Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation

Ann N Y Acad Sci. 2020 Apr;1466(1):51-58. doi: 10.1111/nyas.14169. Epub 2019 Jul 10.

Abstract

Thrombopoietin (Thpo) and its receptor myeloid proliferative leukemia (Mpl) were initially identified as the cytokine signaling that stimulates megakaryopoiesis and platelet production. However, Thpo-Mpl signaling has also been widely characterized as one of the few cytokine systems that directly regulates hematopoietic stem and progenitor cells. The ability of Thpo signaling to stimulate hematopoietic stem cell (HSC) self-renewal has led to the development and utilization of Thpo mimetic drugs to treat hematopoietic diseases with restricted function of HSCs, such as aplastic anemia. This review will cover the mechanisms by which Thpo-Mpl signaling regulates HSCs.

Keywords: cytokine signaling; hematopoietic stem cell; thrombopoietin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Self Renewal / physiology
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Receptors, Thrombopoietin / physiology
  • Signal Transduction / drug effects
  • Thrombopoiesis / physiology
  • Thrombopoietin / pharmacology
  • Thrombopoietin / physiology*

Substances

  • Receptors, Thrombopoietin
  • MPL protein, human
  • Thrombopoietin