Enoxacin-induced modification of the susceptibility of bacteria to phagocytic killing

J Antimicrob Chemother. 1988 Feb;21 Suppl B:19-27. doi: 10.1093/jac/21.suppl_b.19.

Abstract

The effect of enoxacin upon the interaction in vitro of human polymorphonuclear leucocytes with Streptococcus pneumoniae and Pseudomonas aeruginosa was examined. Synergistic killing of these two species of bacteria was observed in the presence of neutrophils and concentrations of enoxacin above the MIC. Enoxacin was able to kill intracellular Str. pneumoniae and Staphylococcus aureus. The activity of glucose-glucose oxidase, an oxygen-dependent bactericidal system which mimics part of the bactericidal system of human neutrophils, was enhanced by pretreatment with enoxacin and several other antibiotics. The effect of antibiotic pretreatment upon the bactericidal activity of an acid extract of neutrophil granules was variable.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cell Extracts / immunology
  • Cell Extracts / pharmacology
  • Enoxacin
  • Glucose Oxidase / antagonists & inhibitors
  • Glucose Oxidase / metabolism
  • Humans
  • Naphthyridines / pharmacology*
  • Neutrophils / drug effects
  • Neutrophils / immunology
  • Neutrophils / microbiology
  • Phagocytosis / drug effects*
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / enzymology
  • Pseudomonas aeruginosa / immunology
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / enzymology
  • Streptococcus pneumoniae / immunology

Substances

  • Anti-Bacterial Agents
  • Cell Extracts
  • Naphthyridines
  • Enoxacin
  • Glucose Oxidase